Orientalism at work?: Dundee’s response to competition from Calcutta, circa 1870-1914

From the late nineteenth century the Dundee jute industry faced intensifying competition from Calcutta. This article examines the responses in Dundee to this competition, focusing upon the ways Dundonians understood Calcutta and India, and how these understandings shaped the debate on possible lines of action. It argues that the diversity of approaches to the threat, inter-linked with the complexities of local politics, led to a concentration of effort on seeking to establish and then strengthen Indian factory legislation. The severity of competition from another empire country posed acute dilemmas for pro-imperial politics in the city: how could such a politics be sustained if the local economy was being so harmed by Calcutta's invasion of Dundee's markets, yet a protective response was ruled out by the realities of imperial policy

Moduli space of stationary vacuum black holes from integrability

We consider the classification of asymptotically flat, stationary, vacuum black hole spacetimes in four and five dimensions, that admit one and two commuting axial Killing fields respectively. It is well known that the Einstein equations reduce to a harmonic map on the two-dimensional orbit space, which itself arises as the integrability condition for a linear system of spectral equations. We integrate the Belinski-Zakharov spectral equations along the boundary of the orbit space and use this to fully determine the metric and associated Ernst and twist potentials on the axes and horizons. This is sufficient to derive the moduli space of solutions that are free of conical singularities on the axes, for any given rod structure. As an illustration of this method we obtain constructive uniqueness proofs for the Kerr and Myers-Perry black holes and the known doubly spinning black rings.Comment: 58 pages. v2: typos fixed, minor clarifications, to appear in Adv. Theor. Math. Phy

CA19-9 as a Potential Target for Radiolabeled Antibody-Based Positron Emission Tomography of Pancreas Cancer.

Introduction. Sensitive and specific imaging of pancreas cancer are necessary for accurate diagnosis, staging, and treatment. The vast majority of pancreas cancers express the carbohydrate tumor antigen CA19-9. The goal of this study was to determine the potential to target CA19-9 with a radiolabeled anti-CA19-9 antibody for imaging pancreas cancer. Methods. CA19-9 was quantified using flow cytometry on human pancreas cancer cell lines. An intact murine anti-CA19-9 monoclonal antibody was labeled with a positron emitting radionuclide (Iodine-124) and injected into mice harboring antigen positive and negative xenografts. MicroPET/CT were performed at successive time intervals (72 hours, 96 hours, 120 hours) after injection. Radioactivity was measured in blood and tumor to provide objective confirmation of the images. Results. Antigen expression by flow cytometry revealed approximately 1.3 × 10(6) CA19-9 antigens for the positive cell line and no expression in the negative cell line. Pancreas xenograft imaging with Iodine-124-labeled anti-CA19-9 mAb demonstrated an average tumor to blood ratio of 5 and positive to negative tumor ratio of 20. Conclusion. We show in vivo targeting of our antigen positive xenograft with a radiolabeled anti-CA19-9 antibody. These data demonstrate the potential to achieve anti-CA19-9 antibody based positron emission tomography of pancreas cancer

Humility: Benedictine spirituality and contemporary psychology in dialogue

Humility is an integral virtue within Benedictine spiritual traditions. It is also the subject of a burgeoning body of empirical literature in the field of psychology. This dissertation undertakes an interdisciplinary dialogue between Benedictine spirituality and contemporary psychological science, exploring the potential for both fields to mutually inform as well as critique respective understandings of humility. Scholarship in Benedictine spirituality has not shown substantial engagement with the field of psychology around the topic of humility since the 1980’s. Likewise, no in-depth analysis of the Benedictine spirituality of humility has been conducted within psychology, despite increasing interest in interdisciplinary projects among psychologists of spirituality and religion. In the body of this dissertation, chapter one sets out to locate this project within the disciplines of practical theology, spirituality studies, and the psychology of religion and spirituality. It also describes the methods used in this dissertation, with particular focus on the dynamics of mutually critical correlation, a method that gives room for both fields to inform, critique, and question the other around their positions regarding the theory and practice of humility. Chapter two presents an in-depth exploration of Benedictine humility, focusing in particular on themes in the Rule of St. Benedict as well as different contemporary interpretations of humility that have emerged over the last thirty years. Chapter three then offers an exploration of the contemporary state of the psychology of humility, documenting the growing body of research on this subject over the last two decades. Chapter four moves into the interdisciplinary analysis of this dissertation, inquiring how contemporary psychological research on humility could potentially inform Benedictine spirituality. Chapter five then switches to consider how insights and perspectives on humility from Benedictine traditions can also inform theoretical perspectives on humility within psychology, as well as applications in psychological interventions that integrate spirituality. Finally, a concluding chapter highlights some points of learning regarding interdisciplinary research on humility in spirituality and psychology, along with questions for future research and a final selection of key points for practice in both fields

Social democracy and the problem of equality: economic analysis and political argument in the United Kingdom

In the context of the recent spread of public and academic concern with economic inequality, this paper examines the evolution of British social democratic thinking about inequality, linking this evolution to the changing debates within economics on this issue. The discussion of the economics of inequality focusses upon the pivotal figure of Tony Atkinson, the most important British economic theorist of inequality, but also an important figure in policy debate since the 1970s

Recently published papers: Renal support in acute kidney injury - is low dose the new high dose?

Despite 21st century definitions, the management of acute kidney injury remains steadfastly rooted in the 20th century with treatment being principally supportive. Protection from potential causative agents is an essential part of management and to that end protection against contrast-induced nephropathy has received yet more attention. When optimization of volume status, haemodynamic parameters, electrolyte and acid-base disturbances have failed we turn to renal replacement therapy. The time 'bought' on renal support gives a period for renal recovery but although renal replacement therapy is widely employed, many management issues remain unanswered, including the timing, duration and the dose of treatment. In contrast to respiratory support for acute lung injury, for example, there is a paucity of large randomized studies addressing these fundamental issues. We describe some recent studies focusing on these issues with the hope that they may lead to better treatment for our patients

Satellite DNA as a target for TaqMan real-time PCR detection of the pinewood nematode, Bursaphelenchus xylophilus

The pinewood nematode (PWN), Bursaphelenchus xylophilus , is a major pathogen of conifers, which impacts on forest health, natural ecosystem stability and international trade. As a consequence, it has been listed as a quarantine organism in Europe. A real-time PCR approach based on TaqMan chemistry was developed to detect this organism. Specific probe and primers were designed based on the sequence of the Msp I satellite DNA family previously characterized in the genome of the nematode. The method proved to be specific in tests with target DNA from PWN isolates from worldwide origin. From a practical point of view, detection limit was 1 pg of target DNA or one individual nematode. In addition, PWN genomic DNA or single individuals were positively detected in mixed samples in which B. xylophilius was associated with the closely related non-pathogenic species B. mucronatus , up to the limit of 0.01% or 1% of the mixture, respectively. The real-time PCR assay was also used in conjunction with a simple DNA extraction method to detect PWN directly in artificially infested wood samples. These results demonstrate the potential of this assay to provide rapid, accurate and sensitive molecular identification of the PWN in relation to pest risk assessment in the field and quarantine regulation